CLINICAL MANAGEMENT OF RADIOLOGICAL EMERGENCIES
In the event of a radiological disaster, medical response will be complicated by the often “silent” and delayed symptoms of acute radiation syndrome (ARS), as well as the high level of fear that many people have of radiation. Detonation of an Improvised Nuclear Device in a major population center is likely to result in many thousands of injured, as well as an even larger population of ”worried well.” A Radiation biodosimetry test, which estimates absorbed radiation dose using an individual’s biological response, will play a critical role in the effective management of a mass scale event.
Introducing the REDI-Dx® Biodosimetry Test system (for investigational use only), a high-throughput, molecular test being developed to estimate absorbed radiation dose from a blood sample collected and stabilized for ambient transport using DxCollect® Blood Collection Tubes. The system estimates dose by analyzing the relative expression of a panel of 18 genes related to cell cycle control, cell signaling, and DNA repair using a combination of multiplex PCR and capillary electrophoresis (CE) fragment analysis and the ABI 3500Dx Genetic Analyzer with associated REDI-Dx® Biodosimetry Interpretative Software.